EVC Mission

MISSION STATEMENT
VISION + CULTURE
ANNUAL REPORT
Policy & Development
PRESS RELEASES
EVC STAFF
RECOGNITION
PUBLICATIONS


Hope Clinic of the Emory Vaccine Center
Emory Center for AIDS Research
Emory University School of Medicine
Yerkes National Primate Research Center
HIV Vaccine Trials Network
International AIDS Vaccine Initiative

EVC Mission

publications

2007 << 2006 << 2005 << 2004 << 2003 << 2002 << 2001

ADAMS, AB, WILLIAMS, MA, JONES, TR, SHIRASUGI, N, DURHAM, MM, KAECH, SM, WHERRY, EJ, ONAMI, T, LANIER, JG, KOKKO, KE, PEARSON, TC, AHMED, R, AND LARSEN, CP: Heterologous immunity provides a potent barrier to transplantation tolerance. Journal of Clinical Investigation, 2003 111:1887-1895

AGRAWAL, S, AGRAWAL, A, DOUGHTY, B, GERWITZ, A, BLENIS, J, VAN DYKE, T, AND PULENDRAN, B: Cutting edge: Different toll-like receptor agonists instruct dendritic cells to induce distinct th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-fos. Journal of Immunology, 2003 171:4984-4989

AGRAWAL, A, LINGAPPA, J, LEPPA, S, AGRAWAL, S, JABBAR, A, QUINN, C, and PULENDRAN, B: Impairment of dendritic cells and adaptive immunity by anthrax lethal factor. Nature, 424: 329-334.

AKDIS, CA, KUSSEBI, K, PULENDRAN, B, AKDIS, M, LAUENER, RP, SCHMIDT-WEBER, CB, KLUNKER, S, ISITMANGIL, G, HANSJEE, N, WYNN, TA, DILLON, S, ERB, P, BASCHANG, G, BLASER, K AND ALKAN, SS: Inhibition of T helper 2-type responses, IgE and eosinophilia by synthetic lipopeptides. European Journal of Immunology,m 2003. 33:2717-2726

ANTIA, R, BERGSTOM, CT, PILYUGIN, SS, KAECH, S AND AHMED, R: Models of CD8+ responses: What is the antigen-independent proliferation program? Journal of Theoretical Biology, 221: 585-598, 2003

BARBER, DL, WHERRY, EJ AND AHMED, R: Cutting Edge: Rapid in vivo killing by memory CD8 T cells. Journal of Immunology, 2003 171: 27-31

BLATTMAN, JN, GRAYSON, JM, WHERRY, EJ, KAECH, SM, SMITH, KA and AHMED, R: Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo. Nature Medicine, 2003, 9:1-8

BU, Z, YE, L, SKEEN, MJ, ZIEGLER, HK, COMPANS, RW, AND YANG, C: Enhancement of immune responses to an HIV Env DNA vaccine by a C-terminal segment of listeriolysin O. AIDS Research and Human Retrovirus, 19:409-20, 2003

BU, Z, YE, L, COMPANS, RW, AND YANG, C: Enhanced cellular immune response against SIV Gag induced by immunization with DNA vaccines expressing assembly and release-defective SIV Gag proteins. Virology, 309:272-81, 2003

BUGE, SL MA, HL, AMARA, RR, WYATT, LS, EARL, PL, VILLINGER, F, MONTEFIORI, DC, STAPRANS, SI, XU, Y, CARTER, E, O’NEIL SP, HERNDON, JG, HILL, E, MOSS, B, ROBINSON, HL, MCNICHOLL, JM: Gp120-alum boosting of a Gag-Pol-Env DNA/MVA AIDS vaccine: poorer control of a pathogenic viral challenge. AIDS Research and Human Retroviruses,19:891-900, 2003.

CAI, J, CHEN, Y, SETH, S. FURUKAWA, S, COMPANS, RW, AND JONES, DP: Inhibition of influenza infection by glutathione. Free Radical Biology and Medicine, 34:928-36, 2003

CHAHROUDI, A, SILVESTRI, G, AND FEINBERG, MB: T cell mediated cytotoxicity using fluorogeneic caspase substrates. Methods, 31:120-126, 2003

CHAPPELL, CP AND JACOB, J: The complexities of T cell receptor heterogeneity. Microbes and Infection, 5: 197-198, 2003

CHEN-COLLINS, A, DIXON, DW, VZOROV, AN, MARZILLI, LG AND COMPANS, RW: Prevention of poxvirus infection by tetrapyrroles. BMC Infectious Diseases 3:9-18, 2003

COSTANTINI, A, MANCINI, S, GIULIODORO, S, BUTINI, L, REGNERY, C, SILVESTRI, G, ANDMONTRONI, M: Effects of cryopreservation on lymphocyte immunophenotype and function. Journal of Immunological Methods, 278: 145-155, 2003

CROTTY, S, FELGNER, P, DAVIES, H, GLIDEWELL, J, VILLARREAL, L, AND AHMED: Cutting edge: Long-term B cell memory in humans after smallpox vaccination. Journal of Immunology, 171:04969-4973, 2003

CROTTY, S, KERSH, EN, CANNONS, J, SCHWARTZBERG, PL, AND AHMED, R: SAP is required for generating long-term humoral immunity. Nature, 421:282-7, 2003.

FOELL, JL, STRAHOUTIN, S, O’NEILL, SP, MCCAUSLAND, MM, SUWYN, C, CHANDER, PN, BAPAT, AS, YAN, X-J, CHIORRAZZI, N, HOFFMANN, MK, AND MITTLER, RS: CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB x NZW F1 mice. Journal of Clinical Investigation 10:1505-18, 2003

GALATI, D, PAIARDINI, M, CERVASI, B, MONTRONI, M, PIEDIMONTE, G, MAGNANI, M, AND SILVESTRI, G: Post-translational regulation of nucleolin in the cell cycle disease of HIV-infected patients. Journal of Infectious Diseases 188:1483-1491, 2003

GARG, S, ORAN, A, SASAKI, S, MARIS, CH, KAPP, JA AND JACOB, J Genetic tagging shows increased frequency and longevity of skin-derived antigen-bearing dendritic cells in vivo. Nature Immunology 9:907-912, 2003

GRAYSON, JM, LANIEWSKI, NG, LANIER, JG, AND AHMED, R: Mitochondrial potential and reactive oxygen intermediates in antigen-specific CD8+ T cells during viral infection. Journal of Immunology 170: 4745-4751, 2003

GUO, L, LU, X, KANG, S-M, COMPANS, RW, AND YAO, Q: Enhancement of mucosal immune responses by chimeric influenza HA/SHIV virus-like particles. Virology, 313:502-13, 2003

HATHCOCK, K, KAECH, S, AHMED, R AND HODES, R: Induction of telomerase activity and maintenance of telomere length in virus-specific effector and memory CD8+ T cells. Journal of Immunology 170:147-152, 2003

JAMIESON, BD, YANG, OO, HULTIN, L, HAUSNER, MA, HULTIN, P, MATUD, J, KUNSTMAN, K, KILLIAN, S, ALTMAN, J, KOMMANDER, K, KORBER, B, GIORGI, J, WOLINSKY S: Epitope Escape Mutation and Decay of Human Immunodeficiency Virus Type 1-Specific CTL Responses. Journal of Immunology, 171: 5372-5379, 2003

JOTWANI, R, PULENDRAN, B, AGRAWAL, S, AND CUTTER, C: Human dendritic cells respond to Porphyromonas gingivalis LPS by promoting a Th2 effector response in vitro. European Journal of Immunology, 33:2980-2986, 2003

KAECH, SM AND AHMED, R: CD8 T cells remember with a little help. Science 300: 263-265, 2003

KAECH, SM, TAN, JT, WHERRY, EJ, KONIECZNY, BT, SURH, CD, AND AHMED, R: Selective IL-7R expression identifies effector CD8 T cells that give rise to long-lived memory cells. Nature Immunology, 9:1191-1198, 2003

KANG, SM, YAO, Q, GUO, Y, AND COMPANS, RW: Mucosal Immunization with Virus-Like Particles of Simian Immunodeficiency Virus Conjugated with Cholera Toxin Subunit B. Journal of Virology. 77: 9823-9830, 2003

KANG, SM AND COMPANS, RW: Enhancement of mucosal immunization with virus-like particles of simian immunodeficiency virus. Journal of Virology, 77:3615-23, 2003

KERSH, EN, KAECH, SM, ONAMI, TM, MORAN, M, WHERRY, WJ, MICELI, MC, AND AHMED, R: T cell receptor signal transduction in antigen specific memory CD8 T cells. Journal of Immunology, 170:5455-5463, 2003

MAHANTY, S, GUPTA, M, PARAGAS, J, BRAY, M, AHMED, R, AND ROLLIN, PE: Protection from lethal infection is determined by innate immune responses in a mouse model of Ebola virus infection. Virology, 312: 415-424, 2003

MAHANTY, S, HUTCHISON, K, AGRAWAL, S, MCRAE, M, ROLLIN, P, AND PULENDRAN, B: Impairment of Dendritic Cells & Adaptive Immunity by Ebola and Lassa Viruses. Cutting Edge, Journal of Immunology, 170:2797-2801, 2003

MARIS, CH, MILLER J, ALTMAN, J AND JACOB, J A transgenic mouse model genetically tags all activitated CD8 T cells. Journal of Immunology, 171:2393-2401, 2003

MILLER, JD, WEBER, DA, IBEGBU, CC, POHL J, ALTMAN JD, AND JENSEN, PE: Analysis of HLA-E Peptide-binding specificity and contact residues in bound peptide required for recognition by CD94/NKG2. Journal of Immunology, 171: 1369-1375, 2003

MUELLER, YM, BOJCZUK, PM, HALSTEAD, ES, KIM, AH, WITEK, J, ALTMAN, JD, KATSIKIS, PD: IL-15 enhances survival and function of HIV-specific CD8+ T cells. Blood, 101:1024-9, 2003

MYERS, L, TAKAHASHI, C, MITTLER, RS, ROSSI, RJ, AND VELLA, AT: 4-1BB costimulation and TLR specific adjuvants combine to optimize peripheral T cell survival, but consequently impair recall responsiveness. Proceedings of the Society of the National Academy of Science (USA), 100:5348-53, 2003

NAYAK, BP, SAILAIGA, G, and JABBAR, AM: Enhancement of gp120-specific immune responses by genetic vaccination with the HIV-1 envelope gene fused to the gene coding for soluble CTLA4. Journal of Virology, 77:10850-10861, 2003

PLEMPER, RK AND COMPANS, RW: Mutations in the putative HR-C region of the measles virus F2 glycoprotein modeulate syncytium formation. Journal of Virology, 77:4181-4190, 2003

PLEMPER, RK, LAKDAWALA, AS, GERNERT, KM, SNYDER, JP, AND COMPANS, RW : Structural features of paramyxovirus F protein required for fusion inhibition. Biochemistry, 42:6645-55, 2003

PULENDRAN, B. Immune Activation: Death, Danger and Dendritic Cells. Current Biology, 14:R30-R32, 2003

RAVKOV, E, MYRICK, C M AND ALTMAN, J D: Immediate Early Effector Functions of Virus-Specific CD8+CCR7+ Memory Cells in Humans Defined by HLA and CC Chemokins Ligand 19 Tetramers. Journal of Immunology, 170, 2461-2468, 2003

RUPRECHT, RM, FERRANTELLI, F, RASMUSSEN, RA, XU, W, KITABWALLA, M, HOFMAN-LEHMANN, R, WILLIAMS, AL, VLASAK, J, IBEGBU, CC, BARRY, A, CHOU, TC, MCCLURE, HM: Neutralizing antibodies: a potent line of defense against acute and chronic SIV infection. Treizième colloque des cent gardes 1-6, 2003

SAILAJA, G, HUSAIN, S, NAYAK, BP, AND JABBAR, AM: Long-term maintenance of gp120-specific immune responses by genetic vaccination with the HIV envelope genes linked to the gene encoding Flt3 ligand. Journal of Immunology, 170: 2496-2507, 2003

SEDER, RA AND AHMED, R: Similarities and differences in CD4+ and CD8+ effector and memory T cell generation. Nature Immunology, 9: 835-842, 2003

SETH, S, VINCENT, A, AND COMPANS, RW: Mutations in the cytoplasmic tail domain of a paramyxovirus fusion glycoprotein rescue syncytium formation and eliminate the HN protein requirement for membrane fusion. Journal of Virology, 77:167-178, 2003

SETH, S, VINCENT, A, AND COMPANS, RW: Activation of fusion by the SER F protein: a low pH-dependent paramyxovirus entry process. Journal of Virology, 77:6520-6527, 2003

SHEDLOCK, DJ, WHITMIRE, JK, TAN, J, MACDONALD, AS, AHMED, R, AND SHEN, H: Role of CD4 T cell help and costimulation in CD8 T cell responses during listeria monocytogenes infection. Journal of Immunology, 170: 2053-2063, 2003

SHEN, H, WHITMIRE, JK, FAN, X, AND AHMED, R: A Specific Role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes. Journal of Immunology 170: 1443-1451, 2003

SILVESTRI, G, SODORA, DL, KOUP, RA, O’NEIL, SP, KAISER, WJ, MCCLURE, HM, STAPRANS, S, AND FEINBERG, MB: Non-pathogenic simian immunodeficiency virus infection of sooty mangabey monkeys is characterized by limited bystander immunopathology and preserved immune regenerative capacity despite chronic high level viral replication. Immunity, 18:1-20, 2003

SILVESTRI G AND FEINBERG M. Turnover of lymphocytes and conceptual paradigms in HIV-infection. Journal of Clinical Investigation 112: 821-824, 2003

SLIFKA, M.K., J.N. BLATTMAN, D.J.D. SOURDIVE, F. LIU, D.L. HUFFMAN, WOLFE, T, HUGHES, A, OLDSTONE, MB, AHMED, R AND M.G. VON HERRATH. 2003. Preferential escape of subdominant CD8+ T cells during negative selection results in an altered antiviral T cell hierarchy. Journal of Immunology, 170:1231-9, 2003

SPIROPOULOU, CF, PETERS, CJ, AND COMPANS, RW: Sin Nombre glycoprotein trafficking and maturation. Virology, 308:48-63, 2003

VAN DER MOST, RG, MURALI-KRISHNA, K, AND AHMED, R: Prolonged presence of effector-memory CD8 T cells in the central nervous system after dengue virus encephalitis. International Immunology, 2003, 15: 119-125

VARGAS-SERRATO, E, CORREDOR, V, AND GALINSKI, MR: Phylogenetic analysis of csp and msp-9 gene sequences demonstrates the close relationship of Plasmodium coatneyi to Plasmodium knowlesi. Infection, Genetics and Evolution 3:67-73, 2003

VILLINGER, F., A.E. MAYNE, P. BOSTIK, K.MORI, K, JENSEN, PE, AHMED, R, AND ANSARI, AA: Evidence for antibody-mediated enhancement of simian immunodeficiency virus (SIV)gag antigen processing and cross presentation in SIV-infected Rhesus macaques. Journal of Virology 77: 10-24, 2003

VZOROV, AN, MARZILLI, LG, COMPANS, RW, AND DIXON, DW: Prevention of HIV-1 infection by phthalocyanines. Antiviral Research, 2003 59:99-109

WAN, J, MARTINVALET, D JI, X, C. LOIS, C, KAECH, SM, VON ANDRIAN, UH, LIEBERMAN, J, AHMED, R, AND MANJUNATH, N: The Bcl-2 family pro-apoptotic molecule, BNIP3 regulates activation-induced cell death of effector cytotoxic T lymphocytes. Immunology 110:10-17, 2003

WANG, J, GUO, Z, DONG, Y, KIM, O, HART, J, ADAMS, A,. LARSEN, CP, MITTLER, RS, AND NEWELL, KA: The Role of 4-1BB in Allograft Rejection Mediated by CD8+ T Cells. American Journal of Transplantation, 3:543-51, 2003

WANG, X, AND ALTMAN, JD: Design of MHC Class I Tetramer / Antigen-Specific T Lymphocyte Dissociation Assays. Journal of Immunological Methods, 280:25-35, 2003

WHERRY, EJ, TEICHGRABER, V, BECKER, TC, MASOPUST, D, KAECH, SM, ANTIA, R, VON ANDRIAN, UH AND AHMED, R: Lineage relationship and protective immunity of memory CD8 T cell subsets. Nature Immunology, 9:225-234, 2003

WHERRY, EJ, BLATTMAN, JN, MURALI-KRISHNA, K, VAN DER MOST, R AND AHMED, R: Viral persistence alters CD8 T cell immunodominance, tissue distribution, and results in distinct stages of functional impairment. Journal of Virology, 2003, 77: 4911-4927.

WILLIAMS, MA, ADAMS, AB, WALSH, MB, SHIRASUGI, N, ONAMI, TM, PEARSON, TC, AHMED, R, AND LARSEN, C: Primary and secondary immunocompetence in mixed allogeneic chimeras. Journal of Immunology, 170: 2382-2389, 2003

WU, Z-Q, KHAN, AQ, SHEN, Y, WOLCOTT, KM, DAWICK, W, WATTS, TH, MITTLER, RS, AND SNAPPER, CM: 4-1BB differentially regulates murine in vivo protein-and polysaccharide-specific Ig isotype responses to Streptococcus pneumoniae. Infection and Immunity, 71:196-204, 2003

YE, L, BU, Z, SKEEN, MJ, ZIEGLER, HK, COMPANS, RW, AND YANG, C: Enhanced immonogenicity of SIV Gag DNA vaccines encoding chimeric proteins containing a C-terminal segment of Listeriolysin O. Virus Research, 97:7-16, 2003


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